Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy and safety of combination of nifuratel tablets with Baofukang suppository on treatment and recurrence of vaginitis in pregnancy

Ruifang Wang, Chunxia Zhang

Department of Pharmacy, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan City, Shandong Province, China;

For correspondence:- Chunxia Zhang Email: haonljsyq215620@163.com

Accepted: 23 May 2021 Published: 30 June 2021

Citation: Wang R, Zhang C. Efficacy and safety of combination of nifuratel tablets with Baofukang suppository on treatment and recurrence of vaginitis in pregnancy. Trop J Pharm Res 2021; 20(6):1267-1272 doi: 10.4314/tjpr.v20i6.24

© 2021 The authors.
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Abstract

Purpose: To investigate the effect and safety of a combination of Nifuratel tablets and Baofukang suppository in the treatment and recurrence of vaginitis in pregnant patients.

Methods: A retrospective analysis was carried out on 100 in-patients admitted between February 2019 and April 2020. They were randomly assigned to control and study groups, with 50 in each group. The control group received Baofukang suppository treatment, whilst the study group was treated with Nifuratel tablets in addition to Baofukang suppository. The two groups were compared with regard to treatment effectiveness, incidence of adverse reactions, recurrence at 1, 2 and 3 months post-treatment; time taken for disappearance of clinical symptoms, and levels of inflammatory factors 1 week after treatment. Moreover, Mental Status Scale in Non-Psychiatric Settings (MSSNS) score, and Quality of Life Index (QLI) score were compared between the groups.

Results: The study group out-performed the control group with respect to treatment effectiveness and QLI score (p < 0.05). Patients in the study group had significantly lower incidence of adverse reactions, degree of recurrence at 1, 2 and 3 months post-treatment, time taken for disappearance of clinical symptoms, expression levels of inflammatory factors, and MSSNS score, when compared to those in control group (p < 0.05).

Conclusion: Combined use of Nifuratel tablets and Baofukang suppository in the treatment of pregnant patients with vaginitis leads to significant treatment efficacy and safety, and reduced recurrence and expression levels of inflammatory factors in patients.

Keywords: Nifuratel, Baofukang suppository, Vaginitis, Pregnancy, Therapeutic effect, Recurrence, Safety